Quantitative Changes in T2* Reflect Remodeling of Both Remote and Ischemic Myocardium in a Murine Heart Failure Model

Eissa Aguor¹, Cees van de Kolok¹, Pieter A.F.M Doevendans¹, Gustav J. Strijkers², Fatih Arslan¹

Noninvasive techniques to characterize the myocardium during infarct development are essential to assess efficacy of novel therapeutics. We have recently shown that quantitative T2* mapping can provide additional information on infarct status and changes in the infarcted myocardium in relatively small murine infarctions after ischemia/reperfusion injury, In this study, we further explored quantitative changes in T2*in the myocardium of a mouse heart failure model induced by severe myocardial infarction. Quantitative T2*values decreased dynamically in the infarct. Interestingly, T2* in remote area also decreased significantly from baseline, most likely as a result of adverse ventricular remodeling of non-infarcted areas after MI.