Meeting Banner
Abstract #1376

Quantitative Changes in T2* Reflect Remodeling of Both Remote and Ischemic Myocardium in a Murine Heart Failure Model

Eissa Aguor1, Cees van de Kolok1, Pieter A.F.M Doevendans1, Gustav J. Strijkers2, Fatih Arslan1

1Cardilogy, UMC, Utrecht, Netherlands; 2Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

Noninvasive techniques to characterize the myocardium during infarct development are essential to assess efficacy of novel therapeutics. We have recently shown that quantitative T2* mapping can provide additional information on infarct status and changes in the infarcted myocardium in relatively small murine infarctions after ischemia/reperfusion injury, In this study, we further explored quantitative changes in T2*in the myocardium of a mouse heart failure model induced by severe myocardial infarction. Quantitative T2*values decreased dynamically in the infarct. Interestingly, T2* in remote area also decreased significantly from baseline, most likely as a result of adverse ventricular remodeling of non-infarcted areas after MI.