Yuchi Liu1,
Xunbai Mei1, Martin W. Zhu2, Saul Flores3,
Parvin Hakimi4, Richard Hanson4, Michiko Watanabe3,
Xin Yu1
1Department
of Biomedical Engineering, Case Western Reserve University, Cleveland, OH,
United States; 2Hawken School, Gates Mills, OH, United States; 3Department
of Pediatrics, Case Western Reserve University, Cleveland, OH, United States;
4Department of Biochemistry, Case Western Reserve University,
Cleveland, OH, United States
This study aimed to analyze the cardiac structure and anatomy of physically energetic PEPCK-Cmus mice, and to evaluate the efficacy of using PEPCK mouse as an animal model of exercised-induced physiological hypertrophy. Multiphase displacement-encoding with stimulated-echo technique was used to obtain in vivo measurements of cardiac anatomy and to quantify two-dimensional left ventricular myocardial wall motion.