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Abstract #1409

Effect of Contrast Dose, Post-Contrast Acquisition Time, Myocardial Regionality, Cardiac Cycle and Gender on Dynamic-Equilibrium Contrast CMR Measurement of Myocardial Extracellular Volume

Christopher A. Miller1, 2, Josephine H. Naish1, Glyn Coutts3, David Clark4, Sha Zhou1, Geoffrey J. M. Parker1, Matthias Schmitt, 12

1Centre for Imaging Sciences & Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom; 2North West Heart Centre and The Transplant Centre, University Hospital of South Manchester, Manchester, United Kingdom; 3Christie Medical Physics and Engineering, The Christie Hospital, Manchester, United Kingdom; 4Alliance Medical Cardiac MRI Unit, Manchester, United Kingdom

This study provides whole-heart, histological validation of; 1. Dynamic-equilibrium cardiovascular magnetic resonance (DynEq-CMR), where myocardial extracellular volume (ECV) is quantified using hematocrit-adjusted myocardial and blood T1 values measured before and after gadolinium bolus; and 2. Isolated measurement of myocardial T1 at a fixed time-point following gadolinium bolus, used as an ECV surrogate.