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Abstract #1457

Hyperpolarized 129Xe Lung Morphometry Method for Estimation of Xenon Concentration Gradients in Chronic Obstructive Pulmonary Disease

Alexei V. Ouriadov1, Adam Farag1, Miranda Kirby1, 2, David G. McCormack3, Grace Parraga1, 2, Giles E. Santyr1, 2

1Robarts Research Institute, Western University, London, Ontario, Canada; 2Department of Medical Biophysics, Western University, London, Ontario, Canada; 3Department of Medicine, Western University, London, Ontario, Canada

The hyperpolarized 129Xe method proposed by Sukstanskii was recently demonstrated for lung morphometry of one healthy volunteer and one cystic fibrosis patient. Accuracy of morphometric parameters depends on a number of factors including the free diffusion coefficient of xenon (D0). Recently, it was hypothesized that the xenon dilution effect explained the observed superior-inferior ADC gradient. Thus, if the D0 distribution provides direct information about the gas concentration gradients in the human lung, it may be useful information for lung disease detection. We propose the method of estimation of the D0 based on the lung morphometry approach.