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Abstract #1461

Estimation of Global Gravity-Induced Gradients and Oxygen Uptake from Hyperpolarized 3He pAO2 Imaging

Hoora Shaghaghi1, Hooman Hamedani1, Stephen J. Kadlececk1, Kiarash Emami1, Yi Xin1, Puttisarn Mongkolwisetwara1, Masaru Ishii2, Milton Rossman3, Rahim Rizi1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Otolarynology, Johns Hopkins Medical Center, Baltimore, MD, United States; 3Pulmonary, allergy and Critical Care Division, University of Pennsylvania, Philadelphia, PA, United States

Gravitational effects were detected in the dependent regions of lung by hyperpolarized 3He pAO2-imaging. In this abstract, a method is presented to estimate a global measure of oxygen uptake and gravitational gradients from two separate 3He pAO2-acquisitions for 22 human subjects. The evaluated oxygen uptakes were in the range of 1-2.5 Torr/s, while smoker and COPD subjects showed lower values. The gravitational gradients averaged to 1 Torr/cm but were less evident for nonsmokers and COPD subjects. The resulted global gradients showed significant correlations with acquired pulmonary function tests for all subjects.