Abstract #1468

A Simultaneous Multi-Breath Scheme for Measurement of ADC, pAO2 and Fractional Ventilation Using 3He MRI in Human

Hooman Hamedani¹, Stephen J. Kadlececk¹, Biao Han¹, Kiarash Emami¹, Yi Xin¹, Masaru Ishii², Milton Rossman³, Rahim Rizi¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; ²Otolarynology, Johns Hopkins Medical Center, Baltimore, MD, United States; ³Pulmonary, allergy and Critical Care Division, University of Pennsylvania, Philadelphia, PA, United States

The use of 3He gas has enabled imaging of both structural and functional aspects of the lung. This work introduces a recently developed scheme for imaging the regional ventilation, partial pressure of oxygen (pAO2) and lung microstructure (ADC) in human lungs using a single protocol with a multi-breath regimen, achievable by use of a patient-driven gas delivery device. The introduced method utilizes the minimum possible amount of hyperpolarized gas while still achieving the highest signal-to-noise possible with the introduced multi-breath maneuver and improves the quality of spin-density maps from which the pAO2 measurements can be made, which in turn can help to produce a more accurate calculation of fractional ventilation from the pAO2 maps themselves.