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Abstract #1485

3D Strain Mapping in the Lung

Alexandra R. Morgan1, 2, Geoff J. M. Parker1, 2, Marietta L.J. Scott3, Josephine H. Naish1

1Centre for Imaging Sciences, Biomedical Imaging Institute, University of Manchester, Manchester, United Kingdom; 2BiOxyDyn Ltd, Manchester, United Kingdom; 3AstraZeneca, Alderley Park, Macclesfield, United Kingdom

Mechanical properties of the lung, such as tissue compliance, become altered in disease. These are difficult to assess on a regional level using traditional methods, such as lung function tests or computed tomography. We present a method to calculate regional tissue motion and strain in 3D using magnetic resonance imaging in conjunction with finite-element image registration techniques. Preliminary results in healthy volunteers are presented suggesting further studies are warranted to assess potential use of these methods in the evaluation of lung disease, such as emphysema and fibrosis.