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Abstract #1487

Quantitative Diffusion-Weighted MR Imaging of Lung Neoplasm: A Promising Method for Delineating Active Tumor

John Chetley Ford1, Kathryn M. Olsen2, Daryl Turlington2, Kai Ding1, Elisabeth Weiss1, Geoffrey D. Hugo1

1Radiation Oncology, Virginia Commonwealth University, Richmond, VA, United States; 2Radiology, Virginia Commonwealth University, Richmond, VA, United States

A respiratory-gated echo-planar diffusion-weighted pulse sequence was investigated by conducting 25 diffusion studies in seven lung cancer patients who had also undergone PET/CT. Quantitative MR diffusion imaging provides delineation of viable lung tumor and exhibits excellent correspondence with PET imaging. Intra-patient repeatability of average apparent diffusion coefficient (ADC) in lung tumor is 4-8%. The remarkable precision of quantitative ADC using this pulse sequence will afford the ability to detect ADC changes in response to treatment and provide meaningful correlation with biological tissue state.