Abstract #1510

Comparison Between Digital Biopsy and MRI Quantification of Hepatic Fat in NAFLD

Samantha Flood¹, Eric Meng², Melanie Beaton³, Lanette J. Friesen-Waldner⁴, Congyu Zhang⁵, Charles A. McKenzie¹

¹Medical Biophysics, The University of Western Ontario, London, Ontario, Canada; ²Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada; ³Department of Medicine, The University of Western Ontario, London, Ontario, Canada; ⁴Medical Biophysics, University of Western Ontario, London, Ontario, Canada; ⁵Engineering, The University of Toronto, Toronto, Ontario, Canada

Non-Alcoholic Fatty Liver Disease (NAFLD) is the leading form of liver disease worldwide in both adults and children. Forty-five patients with confirmed NAFLD underwent multiple MRIs and biopsies. Proton Density Fat Fraction was calculated from IDEAL MRI and area fat fraction was calculated from digitised biopsy samples. Results from two raters were compared to determine reproducibility of the MRI and biopsy derived fat fractions. Fat fractions determined by biopsy and MRI correlate strongly and have similarly high inter-rater reproducibility. These results suggest that MRI is a good non-invasive option for quantifying hepatic fat.