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Abstract #1516

Effect of Gadolinium-Based Contrast Agent on the Relaxation Properties of Water and Fat in Human Liver as Measured in Vivo by 1H MRS.

Gavin Hamilton1, Michael S. Middleton1, Guilherme M. Cunha1, Claude B. Sirlin1

1Department of Radiology, University of California, San Diego, San Diego, CA, United States

Gadolinium-based contrast agents may affect water and fat differently in in vivo liver MR imaging. In this study we evaluate the effect of a hepatocyte-specific MR gadolinium-based contrast agent on T1 and T2 of fat and water in human subjects using a 1H MRS pulse sequence designed to measure T1, T2, and proton density fat fraction (PDFF) simultaneously in a single 21 s breath-hold. We find while gadolinium-based contrast agents significantly reduced T1 and T2 of water, there was no change in fat T1 and T2 and post-contrast water and fat both showed similar T1 values.