Abstract #1521

MRI of Fat Content in the Abdomen and Liver of Obese Mice Following Vertical Sleeve Gastrectomy

Patrick Winter¹, Andriy Myronovych², Rohit Kohli²

¹Radiology, Cincinnati Children's Hospital, Cincinnati, OH, United States; ²Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital, Cincinnati, OH, United States

Fat-suppressed MRI and localized MR spectroscopy were used to quantify abdominal fat content and liver fat content following Vertical Sleeve Gastrectomy (VSG) surgery in a mouse model of obesity. MRI revealed a significant reduction in body fat and liver fat following VSG surgery compared to mice receiving sham surgery followed by calorie restriction, despite similar body weights for these two treatment groups. Liver fat by MR spectroscopy showed excellent agreement with ex vivo tissue analysis. This study demonstrates that MRI can monitor abdominal and liver fat content following weight loss surgery.