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Abstract #1537

Interobserver Agreement of Semi-Automated, Volumetric Analysis of Multiparametric MRI in Patients with Liver Cancer

Susanne Bonekamp1, David Bonekamp1, Vivek Gowdra Halappa2, Jean Francois Geschwind2, John Eng2, Celia Pamela Corona-Villalobos1, Diane Reyes2, Timothy M. Pawlik3, Ihab R. Kamel2

1Radiology, Johns Hopkins University, Baltimore, MD, United States; 2Radiology, JHU, Baltimore, MD, United States; 3 Surgery, JHU, Baltimore, MD, United States

One metric that reflects the quality of data collected in clinical studies is the interobserver agreement of a proposed method. In this study we investigated the interobserver agreement of three different approaches used to obtain functional, volumetric and morphologic MRI-based parameters of response to loco-regional treatment in patients with unresectable Hepatocellular Carcinoma. As hypothesized, semi-automated, volumetric analysis of tumor size, tumor enhancement and ADC values resulted in higher interobserver agreement compared to manual ROI-based analysis of the same parameters