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Abstract #1604

Computational Model of Cortical Bone Pore Water Frequency Distribution, T2' and T2*

Cheng Li1, Henry Ong2, Alexander C. Wright1, Shing Chun Benny Lam3, Felix W. Wehrli1

1Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States; 3Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, United States

Cortical bone water consists of water bound to collagen and mobile water residing in the pore spaces. The two fractions may be separated by bi-exponential fitting attributing the longer component to pore water. However, pore water could be short-lived due to frequency dispersion resulting from the susceptibility difference between bone and pore water. Here we modeled the induced field from high-resolution CT to estimate the pore water decay rate. Results show the T2* of the pore water is ~5ms, the same order as the reported values at 3T. Further investigations are needed along with experimental verification to confirm these findings.