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Abstract #1613

Chemical Exchange and in vivo Intervertebral Disc R1-Rho Dispersion Imaging: A Feasibility Study

Qi Liu1, Zhaoyang Fan1, Yutaka Natsuaki2, Ning Jin3, Wafa Tawackoli1, Gadi Pelled1, Dan Gazit1, Debiao Li1

1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; 2Siemens Healthcare, Los Angeles, CA, United States; 3Siemens Medical Solutions, Columbus, OH, United States

In this study we 1) developed a novel pulse sequence for IVD R1ρ dispersion imaging in vivo, 2) explored the relationship between R1ρ dispersion and pH and concentration in a GAG phantom that mimics IVD composition, and 3) demonstrated the feasibility of the above method on healthy volunteers. Results indicate the proposed method is a promising technique, and has the potential to image important disease biomarkers such as GAG concentration and pH value.