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Abstract #1640

Consistency of Post-Exercise Skeletal Muscle BOLD Response

Andrew D. Davis1, Michael D. Noseworthy2

1Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, ON, Canada; 2Electrical and Computer Engineering, School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada

BOLD imaging is applied to skeletal muscle to examine physiological parameters related to perfusion and oxygenation. Studies involve ROI selection from time series data, and sometimes small ROIs are chosen from the muscle. This study attempted to validate the selection of small ROIs for analysis. A gamma variate curve fitting scheme for post-exercise data was also evaluated. The signal within each muscle was found to be very uniform but differed greatly between muscles. The fitting scheme produced excellent results, with R2 values ranging from 0.967 to 0.997 in exercised muscles, using between 6 and 9 coefficients.