Abstract #1646

Multi-Parametric MRI at 14T for Muscular Dystrophy Mice Treated with Gene Therapy

Donghoon Lee¹, Joshua Park¹, Jacqueline Wicki², Jeffrey Chamberlain², Sue Knoblaugh³, Julie Randolph-Habecker³

¹Radiology, University of Washington, Seattle, WA, United States; ²Neurology, University of Washington, Seattle, WA, United States; ³Fred Hutchinson Cancer Research Center, Seattle, WA, United States

Muscular dystrophy is a group of inherited myogenic disorders with no cure. MRI has some key methods that can potentially provide valuable information in developing effective treatment methods for the deadly disease. Unfortunately, only a limited ability of MRI has been utilized to study muscular dystrophy. Here we performed multi-parametric MRI to evaluate treatment responses for mdx (murine model of muscular dystrophy) mice after adeno-associated virus (AAV) vector mediated gene therapy. Our results show T2, apparent diffusion coefficient and magnetization transfer ratio would be potential MR markers to evaluate the treatment efficacy.