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Abstract #1650

Morphological Assessment of Non-Human Primate Models of Osteoarthritis Using HR-MRI and CT Arthrography

Olivier Beuf1, Denis Grenier2, Fabrice Taborik3, Anne-Laure Perrier2, Kevin Tse Ve Koon2, Laurent Mahieu-Williame2, Luc Magnier4, Thomas Chuzel4, Stphane Martin4, Xavier Pesesse5, Sandra Pietri6, Hugues Contamin3, Emmanuel Chereul4

1Universit de Lyon; CREATIS; CNRS UMR 5220; Inserm U1044, Universit de Lyon, Villeurbanne, France; 2Universit de Lyon; CREATIS; CNRS UMR 5220; Inserm U1044, INSA-Lyon; Universit Lyon 1, Villeurbanne, France; 3Cynbiose, Marcy l'toile, France; 4VOXCAN, Marcy lEtoile, France; 5Bone Therapeuthics, Grosselies, Belgium; 6Service de rhumatologie, Hpital Erasme, ULB, Bruxelles, Belgium

Morphological parameters were assessed on MRI and CT arthrography (CTA) acquisitions, to characterize an induced model of OA by transection of the anterior cruciate ligament (ACL). Three groups of young four year old female primates were constituted and followed over 180 days after surgery. In vivo MR images acquired with the array coil associated with the HR-MRI protocol nicely depicted the cartilage. The cartilage thickness CTA measurements did not show any bias with respect to MRI-based cartilage thickness. Both imaging modalities showed superimposed 3D thickness distributions measurements. Mean cartilage thickness of medial tibia plateaus of the right joint were found constant for control group but decreased significantly for group with ACL transection from D15 to D90 and with intermediate values on D30 and D60.