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Abstract #1660

Bio-Integration Assessment of Rat Knee Cartilage Repair Using in vivo MRI at 7T

Olivier Beuf1, Jean-Christophe Goebel2, Emilie Roeder3, Anne-Laure Perrier2, Denis Grenier2, Pierre Gillet3, Astrid Pinzano3

1Universit de Lyon; CREATIS; CNRS UMR 5220; Inserm U1044, Universit de Lyon, Villeurbanne, France; 2Universit de Lyon; CREATIS; CNRS UMR 5220; Inserm U1044, INSA-Lyon; Universit Lyon 1, Villeurbanne, France; 3PPIA, UMR 7561 CNRS Nancy Universit, Vandoeuvre-Ls-Nancy, France

The biointegration of biomaterials colonized by mesenchymal stem cells or not after implantation in a calibrated full thickness focal lesion in the rat knee were followed using 7T HR-MRI. A four-channel surface coil designed for the simultaneous acquisition of both knee joints of a rat was used. The quality of the MR images obtained with the developed array coils allowed the segmentation of cartilage compartments and measurements of cartilage thickness and volumes. HR-MRI allowed the follow up of cartilage to evaluate in vivo therapeutical responses after chondrogenic biomaterial grafting.