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Abstract #1721

Combined MRI Methods Enable Follow-Up of Bleomycin-Induced Murine Lung Fibrosis

Greetje Vande Velde1, Tom Dresselaers1, Ellen De Langhe2, Jennifer Poelmans1, Rik Lories2, Uwe Himmelreich1

1Biomedical MRI unit/ MoSAIC, KU Leuven, Leuven, Flanders, Belgium; 2Laboratory of Tissue Homeostasis and Disease, Skeletal Biology and Engineering Research Center, KU Leuven, Leuven, Flanders, Belgium

As the course of pulmonary fibrosis progression in rodent models shows substantial interindividual variation, non-invasive techniques are indispensable to dynamically monitor lung inflammation and fibrosis progression to establish the kinetics of pathogenic events or treatment effects for each animal individually. Because imaging tools for the evaluation of lung disease with good temporal and spatial resolution in vivo are limited (e.g. radiotoxicity concerns in CT), we evaluated prospectively and retrospectively gated MRI protocols to visualize disease onset and progression in the bleomycin-induced mouse model for lung fibrosis and confirmed our results with in vivo CT and histology.