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Abstract #1723

MN58b: An Effective Choline Kinase Inhibitor in the Treatment of Rat Brain Gliomas

Manoj Kumar1, Sean Arlauckas1, Sona Saksena1, Gaurav Verma1, Ranjit Ittyerah1, Anatoliy V. Popov1, Harish Poptani1, Edward James Delikatny1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States

Abnormal choline metabolism is a hallmark in cancer diagnosis and is associated with oncogenesis and tumor progression. Increased total choline, predominantly arising from phosphocholine is consistently observed in both pre-clinical tumor models as well as in human tumor studies by 1H MRS. Inhibition of choline kinase using specific choline kinase inhibitors, such as MN58b is a promising new strategy for treatment of brain tumors. We demonstrate the efficacy of MN58b in specifically suppressing total choline levels in an intracranial rat brain tumor model. In-vitro and in-vivo assays were used to characterize the effects of MN58b on tumor cells and on orthotopically grown gliomas in a rat model.