Kimberly Pechman1,
2, Andrew Lozen1, Mona Al-Gizawiy, 23,
Christopher R. Chitambar4, Kathleen M. Schmainda, 25,
Andrew S. Nencka
1Neurosurgery,
Medical College of Wisconsin, Milwaukee, WI, United States; 2Translational
Brain Tumor Program, Medical College of Wisconsin, Milwaukee, WI, United
States; 3Radiology, Medical College of Wisconsin, Milwaukee, WI,
United States; 4Medicine, Medical College of Wisconsin, Milwaukee,
WI, United States; 5Radiology and Biophysics, Medical College of
Wisconsin, Milwaukee, WI, United States
Transferrin receptors are highly expressed on glioblastoma cells, making them a target for therapy. Gallium can function as an iron mimetic that binds to transferring and is incorporated into the cells. The purpose of this study was to evaluate gallium maltolate in the treatment of a U87 xenograft brain tumor model by evaluating changes in tumor blood volume and enhancing tumor volume. The studies demonstrate treating tumors with the novel use of gallium maltolate provides inhibition of tumor volume and angiogenesis.
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