Jin Li1, Yann Jamin1, Craig Cummings1, Jessica K.R. Boult1, John C. Waterton2, Jose Ulloa2, Ralph Sinkus3, Jeffery C. Bamber1, Simon P. Robinson1
1Division of Radiotherapy & Imaging, The Institute of Cancer Research and Royal Marsden NHS Trust, Sutton, United Kingdom; 2Personalised Healthcare and Biomarkers, AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom; 3Centre de Recherche Biomedicale Bichat Beaujon, Clichy, France
Magnetic resonance elastography was used to assess the viscoelastic response in vivo of SW620 xenografts associated with massive central hemorrhagic necrosis induced 24 hours after treatment with the vascular disrupting agent ZD6126. Treatment resulted in a highly significant reduction in the complex shear modulus, elasticity and viscosity, which correlated with a pathologically confirmed necrosis.