Abstract #1754

Accuracy and Precision of DCE-MRI Parameters Estimated by AATH and MTK Models: Evaluations with MMID4 Simulation and Clinical NPC Datasets

Chen-Yi Liu¹, Yen-Peng Liao², Yu-Shi Lin¹,³, Shy-Chyi Chin⁴, Ho-Ling Liu¹,⁴

¹Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan; ²Department of Medical Imaging, Taipei Medical University - Shuang Ho Hospital, Taipei, Taiwan; ³Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Keelung, Taiwan; ⁴Department of Medical Imaging and Intervention, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan

This study aimed to investigate the variability of physiological parameters estimated by the AATH and the mTK models in DCE-MRI. Computer simulation were performed using multiple path, multiple tracer, indicator dilution, 4 region (MMID4) model with various noise added. In addition, the two models were applied in nasopharyngeal carcinoma patients for comparison. Computer simulation quantified the error and variations of the two models, which demonstrated that the AATH was more accurate but less precise than the mTK. Clinical results agreed with the simulation, which showed smaller Ktrans and Veand larger Vp with the AATH than with the mTK model.