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Abstract #1757

Diffusion Weighted MRI as a Predictive Tool for Effect of Radiotherapy in Locally Advanced Cervical Cancer

Sren Haack1, Kari Tanderup2, Lars Fokdal2, Jesper Folsted Kallehauge3, Jacob Lindegaard2, Sune N. Jespersen4, 5, Erik M. Pedersen6

1Dept. of Clinical Engineering, Aarhus University Hospital, Aarhus, Denmark; 2Dept. of Oncology, Aarhus University Hospital, Aarhus, Denmark; 3Dept. of Medical Physics, Aarhus University Hospital, Aarhus, Denmark; 4CFIN/MindLab, Aarhus University, Aarhus, Denmark; 5Dept. of Physics and Astronomy, Aarhus University, Aarhus, Denmark; 6Dept. of Radiology, Aarhus University, Aarhus, Denmark

Diffusion weighted MRI has shown great potential in diagnostic cancer imaging and may also have value for monitoring tumor response during radiotherapy. Patients with advanced cervical cancer are treated with external beam radiotherapy followed by brachytherapy. This study evaluates the value of DW-MRI for predicting outcome of patients with advanced cervical cancer at time of brachytherapy. Volume of hyper-intensity on highly diffusion sensitive images and resulting ADC value for treatment responders and non-responders is compared. The change of ADC and volume of hyper-intensity over time of BT is also evaluated.