Matthew R. Orton1,
Matthew Gwilliam1, Christina Messiou2, David John
Collins1, Veronica A. Morgan2, Helen Young3,
Nandita M. De Souza1, Martin O. Leach1
1CR-UK
and EPSRC Cancer Imaging Centre, Institute of Cancer Research, Sutton,
Surrey, United Kingdom; 2Radiology Department, Royal Marsden NHS
Foundation Trust, Sutton, Surrey, United Kingdom; 3AstraZeneca,
Macclesfield, Cheshire, United Kingdom
This observational report describes statistically significant increases in the contrast arrival time measured using DCE-MRI in a cohort of patients with liver metastases after 1 week and 4 weeks of treatment with an anti-VEGF agent. This result highlights the importance of acquiring data with adequate temporal sampling rates, and the use of robust methods of arrival time estimation when deriving DCE-MRI parameters.
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