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Abstract #1761

Significant Increases in Contrast Arrival Time Measured with DCE-MRI Are Seen After Treatment with an Anti-VEGF Agent

Matthew R. Orton1, Matthew Gwilliam1, Christina Messiou2, David John Collins1, Veronica A. Morgan2, Helen Young3, Nandita M. De Souza1, Martin O. Leach1

1CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research, Sutton, Surrey, United Kingdom; 2Radiology Department, Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom; 3AstraZeneca, Macclesfield, Cheshire, United Kingdom

This observational report describes statistically significant increases in the contrast arrival time measured using DCE-MRI in a cohort of patients with liver metastases after 1 week and 4 weeks of treatment with an anti-VEGF agent. This result highlights the importance of acquiring data with adequate temporal sampling rates, and the use of robust methods of arrival time estimation when deriving DCE-MRI parameters.