14 Tesla MR Imaging of Mice Cholangiocarcinoma Response to Radiofrequency Heating (RFH)-Enhanced Chemotherapy: Towards Intrabiliary RFH-Enhanced Chemotherapy for Pancreatobiliary Cancers

Feng Zhang¹, Thomas Le¹, Xia Wu¹, Tong Zhang¹, Han Wang¹, Stephanie Soriano¹, Donghoon Lee¹, Xiaoming Yang¹

This study validated the feasibility of using 14 Tesla MRI to monitor mice cholangiocarcinoma response to radiofrequency heating(RFH)-enhance chemotherapy. Apparent diffusion coefficient(ADC) is a very useful biomarker for predicting the response of cholangiocarcinoma to RFH-enhanced chemotheray, which was confirmed by subsequent MRI-histology correlation. This new technique may open new revenues for MRI monitored intrabiliary RFH-enhanced chemotherapy for pancreatobiliary malignancies.