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Abstract #1779

Reduced FOV Decreases Susceptibility Artifact in Diffusion-Weighted MRI for Prostate Cancer Detection

Natalie Korn1, John Kurhanewicz1, 2, Suchandrima Banerjee3, Emine U. Saritas, Susan Noworolski1, 2

1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States; 2Graduate Group in Bioengineering, University of California, Berkeley, Berkeley, CA, United States; 3GE Healthcare, San Francisco, CA, United States

Diffusion-weighted imaging (DWI) increases both sensitivity and specificity in detecting prostate cancer in multiparametric MR studies. However, susceptibility artifact at interfaces between the prostate and air, blood, or fecal matter confounds DWI images. A novel, reduced field-of-view pulse sequence to reduce distortion in DWI was evaluated in 27 prostate cancer patients. Visually-assessed distortion was reduced in 75% of patients (p<0.0003) and contrast between tumor and healthy tissue was significantly improved (p<0.02) as compared to the standard DWI sequence.