Hui Zhang1,
Huijun Chen1, Wenchuan Wu1, Xiaoying Wang2,
Feiyu Li2, Chun Yuan1, 3, Hua Guo1
1Center
for Biomedical Imaging Research & Department of Biomedical Engineering,
Tsinghua University, Beijing, China; 2Departement of Medical
Imaging, Peking University First Hospital, Beijing, China; 3Department
of Radiology, University of
Washington, Seattle, WA, United States
Single-shot EPI diffusion weighted imaging, as a traditional method for assessment of disease aggressiveness in clinical application, is burdened by severe distortion as well as low resolution and SNR. In this study, we introduced the interleaved variable density spiral diffusion weighted imaging (VDS-DWI) into the prostate application first time and compares with traditional clinical EPI DWI with different b values and higher resolution. We found that it can provide images with well-reserved structure details and higher SNR and resolution and considerable scan time even in high b value. Our findings indicate that VDS-DWI might be a desirable technique to improve the anatomy structures retention and resolution with considerable SNR and time in clinical prostate and urinary bladder wall detection.