Emily Decelle1, Yannick Berker1, Tilman Schwessinger1, 2, Shulin Wu1, W. Scott McDougal1, Chin-Lee Wu1, Leo L. Cheng1
1Massachusetts General Hospital, Boston, MA, United States; 2Charit Universittsmedizin, Berlin, Germany
Prostate cancer is the most frequently diagnosed malignancy in men worldwide. Radiological imaging is currently unable to detect suspicious areas for targeted biopsy, so randomly conducted biopsies often result in false negatives for early-stage PCa patients. Results from our previous studies of intact tissue samples from PCa patients suggested the existence of metabolic or metabolomic fields, i.e. PCa metabolic information are observed to delocalize from PCa glands and into the surrounding structures that are benign tissue according to histology. In the current study, we test the metabolomic field hypothesis by evaluating prostate biopsy cores for patients suspicious of harboring PCa.