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Abstract #1796

Dynamic Contrast-Enhanced MRI for Detection of Bone Metastases from Prostate Carcinoma: A Study of Kinetic Parameter with Reference Local Voxel Cluster Model

Huarui Du1, Wenchao Cai2, Jue Zhang1, 3, Xiaoying Wang2, Jing Fang1, 3

1College of Engineering, Peking University, Beijing, China; 2Peking University First Hospital, Beijing, China; 3Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China

The aims of this study are to (a) obtain more robust Ktrans and ve map by proposing reference local voxel cluster (RLVC) model as an alternative strategy, which can overcome over-strong assumptions in Tofts model and avoid arterial input function (AIF) or reference tissue (b)prove whether kinetic parameters extracted by RLVC are valid for the detection of bone metastases in patients with prostate carcinoma. Results demonstrate that kinetic parameters are effective on the detection of BM from prostate cancer and extracted Ktrans map could be a potential tool for detection of early bone metastasis.