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Abstract #1801

Registration of Pre and Post Intensity Modulated Radiation Therapy Prostate MRI for Quantification of MR Imaging Marker Changes and Precise Local Prostate Deformations

Robert Toth1, 2, John Kurhanewicz3, Anant Madabhushi2

1Biomedical Engineering, Rutgers University, Piscataway, NJ, United States; 2Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States; 3Radiology, UCSF, San Francisco, CA, United States

In this work we utilize a finite element model with forces on the surface of the prostate to register pre-, post- IMRT MR images for determining pixel-by-pixel changes to the MRI markers, and to quantify the specific local deformations which have occurred as a result of radiation treatment. Results on 7 IMRT MR images demonstrate a RMS error of 2.73 mm with manually selected fiducials and a center of mass distance of 1.84 mm.