Abstract #1816

A New Model for Visualization of Contrast Agent Release from Thermosensitive Liposomes Induced by Laser Based Hyperthermia

Linus Willerding¹, Simone Limmer¹, Martin Hossann¹,², Anja Zengerle¹, Maximilian F. Reiser³, Rolf D. Issels¹,², Lars H. Lindner¹,², Michael Peller³

¹Department of Internal Medicine III, University Hospital of Munich, Ludwig-Maximilians University, Munich, Germany; ²CCG Tumor Therapy through Hyperthermia, Helmholtz Zentrum Mnchen,, German Research Center for Environmental Health, Munich, Germany; ³Department of Clinical Radiology, University Hospital of Munich, Ludwig-Maximilians University, Munich, Germany

Efficacy of systemically applied anti-cancer drugs is limited by insufficient selectivity and thus dose is limited by side effects. To improve the effectiveness of chemotherapy, thermosensitive liposomes (TSL) in combination with hyperthermia are used to target and trigger the release of chemotherapeutics. With MRI contrast agent loaded TSL (CA-TSL) were used for visualisation. Here we present a newly developed setup for MR-monitoring of laser-based hyperthermia in a rat model with CA-TSL for optimized visualisation of content release.