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Abstract #1863

Accumulation of Micron Sized Iron Oxide Particles (MPIOs) in Endothelin-1 Induced Focal Cortical Ischemia in Rats Is Independent of Cell Migration

Dorit Granot1, Erik M. Shapiro2

1Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel; 2Department of Radiology, Michigan State University, East Lansing, MI, United States

Endogenous labeling of stem/ progenitor cells via intracerebroventricular injection of MPIOs has become standard methodology for MRI imaging of adult neurogenesis. While this method is well characterized in the nave rodent brain, it has not been fully investigated in disease models. Here we describe challenges in this methodology that can confound data analysis when this technique is applied to a rat model of stroke.