Meeting Banner
Abstract #1866

Metabolomics Reveals in vivo Significant Impact from Iron Oxide Nanoparticle-Labeled, Grafted Cells on the Host Organism

Verena Hoerr1, Harry Parkes2, Kathrin Halama1, Sonja Mertsch1, Volker Senner1, Astrid Jeibmann1, Cornelius Faber3

1University Hospital Muenster, Muenster, Germany; 2Royal Marsden Hospital, Sutton, United Kingdom; 3University Hospital Mnster, Muenster, Germany

We investigated in vivo the effect of iron oxide nanoparticles (IONPs) on C6 glioma cells with regards to growth behavior and metabolic pathogenesis by MRI and NMR metabolomics using statistical pattern recognition techniques. While tumor growth was similar for labeled and unlabeled tumors, 1H NMR spectra from urine of mice transplanted with iron labeled C6 glioma cells differed significantly from those of untreated cells and showed significant increase in trans-aconitate, N,N-dimethylglycine and 2-phenylproprionate. Our results indicate that IONPs may have significant impact on cell behavior in vivo which may result in metabolic changes superposing the pathological ones.