Abstract #1868

Potential of Newly Developed USPIO P904 in Detecting Lymph Node Metastasis

Yasuo Takehara¹, Naoki Kato², Satoshi Yoshise², Jean-Sebastien Raynaud³, Philippe Robert³, Claire Corot³, Kazuya Hokamura⁴, Harumi Sakahara⁵

¹Radiology, Hamamatsu University Hospital, Hamamatsu, Shizuoka, Japan; ²Guerbet Japan, Chiyoda-ku, Tokyo, Japan; ³Guerbet Research, Roissy CDG, Cedex, France; ⁴Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan; ⁵Radiology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan

Under general anesthesia, five VX2 tumor bearing rabbits were examined with contrast enhanced MRI on 3.0T clinical scanner with phased array knee coil. Newly developed USPIO P904 was intravenously administered at a dose of 100 micro mol Fe/kg. Pre and 24 hrs post-contrast MRI was imaged with 3DT2*GRE. Metastatic and non-metastatic popliteal lymph nodes were excised and the specimens were stained with high sensitivity ion stain, macrophage stain and cytokeratin stain. Close histopathological-MRI correlations disclosed that P904 successfully increased the metastatic foci in the lymph node. Newly developed USPIO P904 may be a promising second generation USPIO after ferumoxtran-10.