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Abstract #1870

Development of a Novel Target Moiety of SPIO Contrast Agent for Effectively Targeting to Pancreatic Cancer Cells in Vitro and in vivo

YunMing Wang1, ShouCheng Wu1, YuJen Chen1

1Department of Biological Science and Technology, National Chiao Tung University, HsinChu, Taiwan

We developed an MR/optical imaging contrast agents for the diagnosis and treatment of pancreatic cancer. A highly sensitive and specific T2 weighted MR-optical imaging agent has been synthesized. The results of the experiments show significant negative contrast enhancement in mucin4 positive cell lines. As a result, we demonstrated that the T2 weighted MR-optical imaging agent can specifically target mucin4 and can be potentially used for the detection of pancreatic cancer.