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Abstract #1884

Vascular Permeability Change as an Imaging Biomarker for Disease Progression and Efficacy of Therapeutic Intervention of Rheumatoid Arthritis: DCE-MRI Study

Jang Woo Park1, Hui-jin Song1, Hee-Kyung Kim1, Jeehye Seo1, Seong-Uk Jin1, Jong Su Baeck1, Moon Han1, Yongmin Chang2, 3, Young-Hwan Lee*4

1Medical & Biological Engineering, Kyungpook National University, Daegu, Korea; 2Diagnostic Radiology, Kyungpook National University, Daegu, Korea; 3Molecular Medicine, School of Medicine, Kyungpook National University , Daegu, Korea; 4Radiology, Daegu Catholic University Medical Center, Daegu, Korea

Magnetic resonance imaging (MRI) can help to diagnose disease progression in rheumatoid arthritis (RA) by measuring potential inflammatory activity from vascular permeability. To calculate permeability value, dynamic contrast enhanced (DCE) MRI and relating pharmacokinetic models which was defined by Tofts and Kermode was used. Vascular permeability reflects angiogenesis and vascular structural changes the blood vessel wall by Rheumatoid arthritis, so this study make vascular permeability map and compare permeability value for each RA progression and the efficacy of therapeutic intervention. This study demonstrates the successful application of vascular permeability for inflammatory disease such as RA, and permeability value form DEC-MRI can be quantitative index of RA diagnose.