Abstract #1892

Trimodality Detection of Magnetic Megaparticles for Simultaneous Tracking of a Large Number of Primary Human Cells Assembled in Collagen Matrices

David P. Cormode¹, Willem J M Mulder², Erik M. Shapiro³

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States; ²Translational and Molecular Imaging Institute, Mount Sinai School of Medicine, New York, NY, United States; ³Radiology, Michigan State University, East Lansing, MI, United States

We herein report the development and use of a new type of particle as a contrast agent for MRI-related imaging: a magnetic megaparticle. We will report the synthesis and characterization of the megaparticle, as well as the results of long-term biocompatibility experiments and cell-labeling. The particle could be used for tracking very large numbers of cells using a hand held magnetic device, which we also integrated into an iPhone based imaging system. The particle facilitates optical imaging, as well. The megaparticle will be broadly applicable for the study of a variety of diseases.