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Abstract #1896

Characterization of Gd-Based Contrast Agents Encapsulated in Thermosensitive Liposomes as Potential Tool for MRI Assisted Hyperthermia

Michael Peller1, Martin Hossann2, Zulfiya Syunyaeva2, Rolf D. Issels2, Maximilian F. Reiser1, Lars H. Lindner2

1Institute for Clinical Radiology, University Hospital Munich, Ludwig-Maximilians University,, Mnchen, Germany; 2Department of Internal Medicine III, University Hospital Munich, Ludwig-Maximilians University, Mnchen, Germany

Thermosensitive liposomes (TSL) with encapsulated contrast agents (CA) have been proposed for MRI-assisted thermotherapy in tumors. For such purpose an effective temperature induced r1-relaxivity change and stability in the presence of serum components is needed. Here, temperature induced r1 change of 6 approved Gd-based CAs comprising diverse chemical structures and charges encapsulated in phosphatidyldiglycerol (DPPG2)-TSL were characterized. The shelf life of TSL was also investigated.