Abstract #1949

NMR-Based Metabolite Profiling of Fecal Extracts from Colorectal Cancer in China: An Initial Study

Yan Lin¹, ChengKang Liu¹, ZhiWei Shen¹, RenHua Wu¹

¹Medical Imaging Department, Second Affiliated Hospital, Shantou University Medical College, Shantou, Guang Dong, China

This preliminary results based on 1H NMR spectroscopy and partial least squares discriminant analysis (PLS-DA) demonstrated that metabolites differences of fecal extracts between CRC patients and healthy controls can be identified that may be important in the early detection of CRC in China. The observed low levels of SCFA (acetate, butyrate and propionate) are consistent with previous reports[3,4], which has been associated with the development of colorectal cancer, seems to be the most effective marker of fecal extracts for differentiating CRC patients from healthy controls.