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Abstract #1974

Spectroscopic Imaging of Brain Metabolism in a Mouse Model of Human Glioma-Initiating Cells: A Longitudinal Study at 14.1 T

Mlanie Craveiro1, Cristina Cudalbu1, Denis Marino2, Ivan Radovanovic2, Virginie Clment-Schatlo2, Rolf Gruetter3, 4

1Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 2Department of Clinical Neurosciences, University Hospital of Geneva, Geneva, Switzerland; 3Laboratory for Functional and Metabolic Imaging, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 4Departments of Radiology, Universities of Lausanne and Geneva, Lausanne and Geneva, Switzerland

Mouse models of human gliomas have been developed by injection of fresh or cultured glioma-initiating cells (GIC), leading to slow infiltrative or fast developing and aggressive brain tumours. However, although brain tumours have been extensively studied, only a few studies have focused on the metabolic changes during their development. In this study, we imaged the metabolic changes occurring during tumour growth after an injection of cultured GIC using proton magnetic resonance spectroscopic imaging, which allowed for sensitive tumour detection prior to any visual signs on anatomical images, thus insuring an optimal evaluation of the first metabolite alterations.