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Abstract #1978

Impaired Pyruvate Carboxylase and Pentose Phosphate Pathway in APP-PS1 Mouse Model of Alzheimers Disease

Anant Bahadur Patel1, Vivek Tiwari1

1NMR Microimaging and Spectroscopy, CSIR-Centre for Cellular and Molecular Biology, Hyderabad, Andhra Pradesh, India

Alzheimers Disease (AD) is one of the most common neurodegenerative disorders characterized by progressive memory impairment, disordered cognitive functions and perturbed synaptic transmission. The present study evaluates metabolic fluxes via pyruvate carboxylase (PC), pentose phosphate (PPP) and pyruvate dehydrogenase (PDH) pathways in 20 months old APP-PS1 mouse brain by using 1H-[13C]-NMR spectroscopy in conjunction with infusion of [2-13C]glucose. Our results indicate that fluxes through PC, PPP and PDH pathways are severely impaired in 20 months old APP-PS1 mice.