Impaired Pyruvate Carboxylase and Pentose Phosphate Pathway in APP-PS1 Mouse Model of Alzheimers Disease

Anant Bahadur Patel¹, Vivek Tiwari¹

Alzheimers Disease (AD) is one of the most common neurodegenerative disorders characterized by progressive memory impairment, disordered cognitive functions and perturbed synaptic transmission. The present study evaluates metabolic fluxes via pyruvate carboxylase (PC), pentose phosphate (PPP) and pyruvate dehydrogenase (PDH) pathways in 20 months old APP-PS1 mouse brain by using ¹H-[¹³C]-NMR spectroscopy in conjunction with infusion of [2-¹³C]glucose. Our results indicate that fluxes through PC, PPP and PDH pathways are severely impaired in 20 months old APP-PS1 mice.