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Abstract #1988

Electron Paramagnetic Resonance Spectrometry and Imaging in Melanomas: A Comparison Between Pigmented and Non-Pigmented Human Malignant Melanomas.

Quentin Godechal1, Ghanem Ghanem2, Martin Cook3, Bernard Gallez1

1Biomedical Magnetic Resonance, University of Louvain, Brussels, Belgium; 2Universite libre de Bruxelles, Brussels, Belgium; 3Department of Histopathology, Royal Surrey County Hospital, Guildford, United Kingdom

In this study, we proposed to use EPR imaging as a tool to map the concentration of melanin inside ex-vivo human pigmented and non-pigmented melanomas and to correlate this cartography with anatomo-pathology. The importance of the pigmentation for EPR measurement was unambiguously demonstrated. Moreover, EPR images accurately reflected the distribution of melanin pigments within melanoma samples.