Abstract #1988

Electron Paramagnetic Resonance Spectrometry and Imaging in Melanomas: A Comparison Between Pigmented and Non-Pigmented Human Malignant Melanomas.

Quentin Godechal¹, Ghanem Ghanem², Martin Cook³, Bernard Gallez¹

¹Biomedical Magnetic Resonance, University of Louvain, Brussels, Belgium; ²Universite libre de Bruxelles, Brussels, Belgium; ³Department of Histopathology, Royal Surrey County Hospital, Guildford, United Kingdom

In this study, we proposed to use EPR imaging as a tool to map the concentration of melanin inside ex-vivo human pigmented and non-pigmented melanomas and to correlate this cartography with anatomo-pathology. The importance of the pigmentation for EPR measurement was unambiguously demonstrated. Moreover, EPR images accurately reflected the distribution of melanin pigments within melanoma samples.