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Abstract #2028

Real-Time Single-Voxel Water Proton Spectroscopy and Echo-Planar Imaging Sensitivity to the BOLD Effect at 3 and 7 T.

Yury Koush1, 2, Mark A. Elliott3, Frank Scharnowski, 24, Klaus Mathiak5, 6

1Department of Radiology and Medical Informatics - CIBM, University of Geneva , Geneva, Switzerland; 2Institute of Bioengineering, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland; 3Center for Magnetic Resonance and Optical Imaging (CMROI), Department of Radiology,, University of Pennsylvania, Philadelphia, PA, United States; 4Department of Radiology and Medical Informatics - CIBM, University of Geneva, Geneva, Switzerland; 5Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany; 6Institute of Neuroscience and Medicine (INM-1), Research Center Jlich, JARA - Translational Brain Medicine, Aachen, Germany

It has been shown that spin-echo single-voxel proton spectroscopy (SVPS) can be used for spatially specific BOLD neurofeedback at 7 T. However, it is not clear how neurofeedback based on SVPS compares to the more commonly used gradient-echo echo-planar imaging (EPI) based neurofeedback. We showed that the data quality of real-time SVPS and EPI are comparable at 3 T. At 7 T, the real-time SVPS does not reach the quality of EPI and needs to be further improved. However, the 7 T spin-echo acquisition might target specifically microvascular contributions to the BOLD effect and benefit from increased spatial resolution.