Enhancement of 2-Hydroxyglutarate Detectability by Triple-Refocusing Difference Editing at 3T in vivo

Changho Choi¹, Sandeep Ganji², Akshay Madan¹, Robert Bachoo¹, Ralph DeBerardinis¹, Elizabeth A. Maher¹

Given the great potential of 2HG as a biomarker in the diagnosis and management of glioma patients as well as the workup of an undiagnosed mass, the capability of precise detection of 2HG in vivo is extensively needed. In 1H-MRS, the 2HG signals are severely overlapped with other metabolite signals. Specifically, because of the close proximity of the 2HG 2.25 ppm resonance to the GABA 2.29 ppm resonance, when the 2HG levels are relatively low, 2HG estimation is elusive. Here we present 2HG measurements without considerable GABA contamination in patients in vivo, achieved by constant-TE triple-refocusing difference editing at 3T.