High-Resolution Localized 2D J-Resolved Spectroscopy Via Intermolecular Single-Quantum Coherences

Yuqing Huang¹, Zhiyong Zhang¹, Shuhui Cai¹, Zhong Chen¹

Localized 2D J-resolved spectroscopy can separate chemical shifts and J couplings into two different dimensions. It is widely used for the detection of metabolites in biological tissues, even in in vivo study. However, due to the intrinsic magnetic susceptibility in biological tissues, the localized 2D J-resolved spectrum is usually suffered from field inhomogeneity. In this report, a new pulse sequence based on intermolecular single-quantum coherences is presented to obtain localized 2D J-resolved spectrum in inhomogeneous fields, which is potentially useful for studying biological metabolites.