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Abstract #2051

Optimized Twice-Refocused Adiabatic Spin Echo Sequence for Diffusion Weighted Imaging of Humans at 7T

Priti Balchandani1, 2, Deqiang Qiu2

1Radiology, Mount Sinai School of Medicine, New York, NY, United States; 2Radiology, Stanford University, Stanford, CA, United States

Diffusion weighted imaging (DWI) at higher field strengths, such as 7 Tesla, may benefit from increased signal-to-noise ratio but suffers from susceptibility to B1-inhomogeneity. This effect is particularly pronounced when using a twice-refocused spin echo DWI sequence to mitigate eddy current effects. We have employed the adiabatic SLR algorithm for RF pulse design to design optimized B1-insensitive 180&[deg] RF pulses and used them to replace the standard 180&[deg] pulses in a twice-refocused spin echo DWI sequence. We show improved diffusion weighted images of the human brain at 7T with more uniform SNR when using this method when compared to the standard non-adiabatic approach.