Meeting Banner
Abstract #2055

Full Optimization of Multi-Shell Diffusion Acquisition Schemes for Advanced Microstructural Imaging

Silvia De Santis1, Yaniv Assaf2, Derek K. Jones1

1CUBRIC Cardiff University, Cardiff, United Kingdom; 2Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel

A comprehensive optimisation of the experimental acquisition scheme for advanced microstructural imaging is developed, optimising and comparing different approaches reported in the literature though both Monte-Carlo simulations and in vivo acquisitions. As a result, an optimised protocol for multi-shells acquisitions is proposed, that balances scan duration with accuracy/precision on the estimated parameters, needing only a 12 minutes acquisition for whole-brain maps of the axonal density and the fibre orientation.