Russell Glenn1, Ali Tabesh1, Jens H. Jensen1
1Radiology and Radiological Sciences, Medical University of South Carolina, Charleston, SC, United States
Diffusion MRI (dMRI) measurements are positively biased by noise from use of magnitude reconstructed images. The effects of the noise bias increase with decreasing signal-to-noise ratio (SNR), which can be problematic in high resolution dMRI acquisitions. A simple, retrospective noise correction technique is described and a weighted linear least squares fitting algorithm is presented for diffusional kurtosis imaging (DKI). Noisy phantom data is analyzed in DKI datasets with variable SNR, and the results of the noise correction are compared to uncorrected and reference data. Noise correction substantially reduces the bias in kurtosis estimates.