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Abstract #2086

Influences of B-Value on the Reproducibility and Accuracy of Diffusion Kurtosis Imaging

Ming-Chung Chou1, Wan-Hsin Wen1, Sheng-Fang Huang1, Cheng-Wen Ko2, Ping-Hong Lai3

1Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan; 2Department of Computer Science and Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan; 3Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Diffusion kurtosis imaging (DKI) was demonstrated to successfully estimate the non-Gaussian distribution of water diffusion in vivo and has been applied in many clinical applications. Similar to diffusion tensor imaging, b-value is an important factor in the measurement of DKI indices and may have influential effects on them. Rapid DKI with three b-values was proposed to obtain DKI indices in clinically acceptable time, but the results may be affected by the choice of b-value. This study performed repeated measurement to investigate the effects of b-value on the reproducibility and accuracy of DKI indices and found that both reproducibility and accuracy were impacted by b-values.