Abstract #2086

Influences of B-Value on the Reproducibility and Accuracy of Diffusion Kurtosis Imaging

Ming-Chung Chou¹, Wan-Hsin Wen¹, Sheng-Fang Huang¹, Cheng-Wen Ko², Ping-Hong Lai³

¹Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan; ²Department of Computer Science and Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan; ³Department of Radiology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Diffusion kurtosis imaging (DKI) was demonstrated to successfully estimate the non-Gaussian distribution of water diffusion in vivo and has been applied in many clinical applications. Similar to diffusion tensor imaging, b-value is an important factor in the measurement of DKI indices and may have influential effects on them. Rapid DKI with three b-values was proposed to obtain DKI indices in clinically acceptable time, but the results may be affected by the choice of b-value. This study performed repeated measurement to investigate the effects of b-value on the reproducibility and accuracy of DKI indices and found that both reproducibility and accuracy were impacted by b-values.